On Sunday, September 21, 2025, the Arizona Cardinals (2-0) hit the road for an NFC West battle against the San Francisco 49ers (2-0) at Levi's Stadium.
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49ers vs. Cardinals: Sept. 21 Viewing Options
- When: Sunday, September 21, 2025 at 4:25 p.m. ET
- Where: Levi's Stadium in Santa Clara, California
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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49ers vs. Cardinals Insights
- The 49ers have averaged 4.0 more points scored this season (21.5) than the Cardinals have allowed (17.5).
- The Cardinals have averaged 6.5 more points scored this season (23.5) than the 49ers have allowed (17.0).
- Arizona's defense has allowed an average of 333.5 yards per game this season, 30.5 yards fewer than the 364.0-yard average from San Francisco's offense. SF picks up 5.4 yards per play and the Arizona gives up 4.8.
- The total number of yards Arizona's offense has put up and San Francisco's defense has given up per game this season is within 16.0 yards (284.5 compared to 268.5). Arizona averages 5.6 yards per play, while San Francisco gives up 4.8.
- The Cardinals defense has given up an average of 78.0 yards per game to opposing running games this season. That is 20.0 fewer yards than the 49ers have gained running the football (98.0).
- The Cardinals have averaged 114.0 yards per game on the ground this season, 11.5 more yards than the 49ers have allowed to opposing rushing attacks (102.5).
- San Francisco has committed one more turnover this season (3) than Arizona's defense has forced (2).
- San Francisco has forced two more turnovers this season (3) than Arizona has committed (1).
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49ers' Upcoming Schedule
| Date | Opponent | Score | TV |
|---|---|---|---|
| 9/7/2025 | at Seattle | W 17-13 | FOX |
| 9/14/2025 | at New Orleans | W 26-21 | FOX |
| 9/21/2025 | Arizona | - | FOX |
| 9/28/2025 | Jacksonville | - | FOX |
| 10/2/2025 | at Los Angeles | - | Amazon Prime Video |
| 10/12/2025 | at Tampa Bay | - | CBS |
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Cardinals' Upcoming Schedule
| Date | Opponent | Score | TV |
|---|---|---|---|
| 9/7/2025 | at New Orleans | W 20-13 | CBS |
| 9/14/2025 | Carolina | W 27-22 | CBS |
| 9/21/2025 | at San Francisco | - | FOX |
| 9/25/2025 | Seattle | - | Amazon Prime Video |
| 10/5/2025 | Tennessee | - | CBS |
| 10/12/2025 | at Indianapolis | - | FOX |